A bio-imprinted urease biosensor: Improved thermal and operational stabilities
Articles > Article · 2007
Authors: Mustafa Teke, Mustafa Kemal SEZGINTURK, Erhan DİNÇKAYA, Azmi TELEFONCU
Talanta, Journal Indexed in SCI Expanded, International, WoS, 2007, vol 74, pp 661-665
DOI: 10.1016/j.talanta.2007.06.031
Summary
Despite the increasing number of applications of biosensors in many fields, the construction of a steady biosensor remains still challenging. The high stability of molecularly bio-imprinted enzymes for its substrate can make them ideal alternatives as recognition elements for sensors. Urease (urea aminohydrolase, EC 3.5.1.5), which catalysis the hydrolysis of urea to ammonia and carbon dioxide, has been used in immobilized form in artificial kidney for blood detoxification. According to one report approximately half a million patients worldwide are being supported by haemodialysis.