Does body mass index have prognostic significance for patients with idiopathic pulmonary fibrosis?
Bildiriler > Özet Bildiri · 2018
Yazarlar: Nesrin MOĞULKOÇ BISHOP, Martina Sterclova, Veronika Mueller, Jan Kus, Marta Hajkova, Dragana Jovanovic, Jasna Tekavec-Trkanjec, Marketa Janotova, Martina Vasakova
Idiopathic interstitial pneumonias, Fransa, Uluslararası, Sözlü Sunum, Özet Bildiri, 2018-2018, Wos, cilt 52, ss PA2210-PA2210
DOI: 10.1183/13993003.congress-2018.pa2210
Özet
Aim: A high body mass index (BMI) impacts beneficially on survival in patients with COPD and chronic respiratory insufficiency. We aimed to assess whether body mass index influences survival of patients with idiopathic pulmonary fibrosis. Methods: We examined the relationship between BMI and survival in patients with IPF enrolled to the EMPIRE registry. All had a diagnosis of IPF based on ATS/ERS/JRS/ALAT consensus statement from 2011. Height and body weight were ascertained at the first consultation. Results: We had data on 2003 patients recruited from seven countries. The median age at first consultation was 68 years (50 to 82). There were 1396 men. At presentation, 15 were underweight (BMI <18.5), 418 were of normal weight (BMI 18.5 to 25), 896 were overweight (BMI 25 to 30) and 674 were obese (BMI >30). On Kaplan-Meier survival analysis, the difference in survival between these categories was not statistically significant (p=0.197). The trend was for greater BMI to be associated with longer survival. Taking normal weight as the reference, the hazard ratios for death were: underweight; 1.53, overweight; 0.90, obese; 0.81. Conclusions: The survival curve shows a worse survival for the underweight but larger numbers need to be analysed. Causality has not been examined but it may be beneficial to give dietary advice to those of low BMI. The EMPIRE registry is supported by Boehringer Ingelheim.