Functionalization of chitosan by click chemistry
Conference paper > Full Text ยท 2017
Authors: Catalina Natalia Cheaburu-Yilmazi, Sinem Yaprak KARAVANA, Onur YILMAZ
AIP Conference Proceedings, Romania, International, Verbal, Full Text, 2017-2017, Scopus, vol 1919, pp 020009-020009
DOI: 10.1063/1.5018504
Summary
Chitosan modification represents a challenge nowadays. The variety of compounds which can be obtained with various architectures and different functionalities made it attractive to be used in fields like pharmacy and material science. Presents study deals with the chemical modification of chitosan by using click chemistry technique. The study adopted the approach of clicking azidated chitosan with a synthesized alkyne terminated polymer i.e. poly N isopropylacrylamide with thermoresponsive properties. Structures were confirmed by the FT-IR and HNMR spectra. Thermal characterization was performed showing different thermal behaviour with the chemical modification. The final synthesized graft copolymer can play important role within pharmaceutical formulations carrying drugs for topical or oral treatments.