Metabolic regulation of leptin: mini review
Makaleler > Derleme · 2023
Yazarlar: Onur ORAL, Pınar Tatlıbal
Scientific Chronicles, ESCI İndekslerine Giren Dergi, Uluslararası, Emerging Sources Citation Index (ESCI), 2023, ss 20-29
Özet
<p>Being discovered in 1994, the leptin hormone unites with special receptors in the body, and they together control body weight, food intake, energy expenditure, and generally, it’s secreted by adipose tissues. Besides adipose tissues, leptin is also produced in placental trophoblasts, heart, bone, and the like fat tissues and fundus epithelium. Leptin passes to the brain with a special transportation system by blood path. In obese, this transportation system weakens and forms a resistance against leptin. Because of their structural similarities to cytokines, they are also classified as a cytokine. In case of the lack of leptin or resistance, it results in obesity, diabetes, and infertility. In the search for scientific literature related to this review the US National Library of Medicine (PubMed) used MEDLINE and SportDiscus data and the terms “Leptin”, “exercise”, “obesity”, and “osteogenesis” were used. The relevant literature has also taken its source from the research of relevant articles from reference lists derived from data studies. The primary effects of leptin exist in lymphoid organ homeostasis, bone volume, blood pressure, growth, antiobesity, fertility, hematopoiesis, angiogenesis, and many systems like the T lymphocyte system. Growth hormone treatment decreases body weight and also in a roundabout way, leptin Leptin can be said to it’s also effective on growth apart from the fact that many factors play role in the synthesis and secretion of leptin, regular exercising decreases leptin levels and affects inhibiting obesity. On the other hand, there is a close relationship between leptin levels, diabetes, and obesity. So, leptin treatment with an appropriate exercise program is expected to yield positive results in diabetes and metabolic syndrome.</p>