The Topical Effect Of Intravesical Oxybutynine On Rat Bladder
Makaleler > Tam Makale · 1997
Yazarlar: Bülent Semerci, Erdal APAYDIN, Taner AKALIN, Özlem İlbey, Ayhan Verit, Atalay Güran, Özcan Erhan, Nurullah Mülazımoğlu
The Journal of Tepecik Education and Research Hospital, Uluslararası, 1997, cilt 7, ss 1-4
Özet
Oxbutynine applied intraves:icaUy has been repoded to have exceHent efficacy in the treatınentofneurogenic biadde:r dys:function without significantsystenı:k antkhoHne:rgic si de effects.But, the topical effects o'f inttavesical oxybuty:nine on the bladder are undear'and safety of thelocal Hssue is not established.The aimoHhis study was to evaluate t.he topkal effeds of intraveskal oxybutynine on an animal model.Intravesical oxybu:.tyninewas instilled into rat bladder in graded doses by ırepeated cathetererizations a:fter 5 doses were given, on the thi:deenth day, bladder wei•e reseded fo:r histologicalstudy.In the high dose group, systemic absorbtion from the bladder caused weight lossami cachexia.In the same group,mucosal ulcerationswere also deteded on the bladders.In the other groups, the:re was no dear evidence of drug-related mucosal change on bladderwall.Our findings support that the :usage of intravesical oxbutynine at approp:riate dose is safe the locaUissue.