The Frequency of XRCCl DNA Repair Gene A399G Polymorphism in The Western Anatolia
Makaleler > Tam Makale · 2007
Yazarlar: Tuğçe Sever, Sacide Pehlivan
European Journal of Therapeutics, Uluslararası, 2007, cilt 13, ss 22-25
DOI: 10.58600/eurjther.2007-13-1-1406-arch
Özet
The aim of this study is to determine the frequency of polymorphism in codon 399 region of XRCC1 gene in the healthy Western Anatolian population. XRCC1-399 polymorphism is studied in the control group of 100 people living in Izmir, Turkey, who don't have a cancer story, using the method of PCR- RFLP (Msp I Restriction Endonuclease enzyme). The followings are found out as a result of the analyses: the frequency of the ones having A/A genotype is 44.0 %, the frequency of the ones having A/G genotype is 41.0 % and the frequency of the ones having G/G genotype is 15.0 %. Allel frequencies are found to be 64.5 % for A nucleotide and 35.5 % for G nucleotide. When the results obtained are compared with various populations, the homozygosity rate for Allel A and Allel G is determined to be at a similar value as the Indian, American, English, Korean and Chinese populations.