In vivo/in vitro correlations of nitrofurantoin matrix tablet formulations
Makaleler > Tam Makale · 1996
Yazarlar: Hatice Yeşim KARASULU, g ertan, Timur KÖSE, T GÜNERİ
European Journal of Drug Metabolism and Pharmacokinetics, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 1996, cilt 21, ss 27-31
DOI: 10.1007/bf03190275
Özet
In our recent study, a new sustained release dosage form of nitrofurantoin (nft) as matrix tablets by 2(2) factorial design has been prepared by using different drug:polymer ratios. The effect of the polyvinylpyrolidone contents of nft matrix tablets on dissolution rate and bioavailability of the drug have been evaluated. The ideal formulation which fitted at USP XXII dissolution norms was tested by in vivo experiments. The satisfactory correlation was also obtained between the in vivo and the in vitro results.