Nörodejeneratif Süreçler ve Ağrıda İmmunomodülasyon,
Kitaplar > Mesleki Kitap · 2009
Yazarlar: Özlem YILMAZ
Mesleki Kitap, 2009, Ege Üniversitesi, Üniversite, Türkiye, İzmir, Ulusal
Özet
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<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Unresolved Mention"></w:LsdException> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Smart Link"></w:LsdException> </w:LatentStyles> </xml><![endif]--><!--[if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Normal Tablo"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman",serif;} </style> <![endif]--> <span style="mso-ansi-language: TR">Nörodejeneratif hastalıklar ve kronik ağrılar, günümüzde giderek daha çok karşılaşılan ve yaşam kalitesini bozan durumlardır. Ayrıca <span style="mso-spacerun:yes"> </span>iş gücü kaybına<span style="mso-spacerun:yes"> </span>yol açarak topluma ekonomik yük de getirmektedirler. Bu hastalık ve bulguların tedavi edilebilmesi için öncelikle <span style="mso-spacerun:yes"> </span>hangi mekanizmalarla oluştuklarının anlaşılması gerekir. Bu alanlara yönelik çalışmalar sırasında, <span style="mso-spacerun:yes"> </span>immun süreçlerin <span style="mso-spacerun:yes"> </span>söz konusu klinik durumlara önemli katkıları olduğu ortaya çıkmıştır. Nörodejeneratif<span style="mso-spacerun:yes"> </span>ve inflamatuar hastalıkların,<span style="mso-spacerun:yes"> </span>20-30 yıl öncesine kadar birbirinden bağımsız hastalıklar olduğu düşünülmekte; hatta beyin, immun ayrıcalığı olan bir organ olarak değerlendirilmekteydi. Ayrıca immun sistemlerin, ağrının ortaya çıkışında değil sonucunda tetiklendiği düşünülmekteydi. Son yıllarda yapılan çalışmalar; Alzheimer hastalığı, Parkinson hastalığı, Multipl skleroz gibi nörodejeneratif hastalıkların ve ağrının farklı tiplerinin ortaya çıkışında inflamatuar süreçlerin önemli rol oynadığını göstermektedir. Bunların ortaya çıkmasında rol oynayan mekanizmaların tanımlanması, yeni tedavi yaklaşımlarını oluşturmada çok önemlidir. Biz bu kitapta önce, santral sinir sistemini modüle eden immunolojik mekanizmalar ve bunların nörodejeneratif süreçlerdeki etkileriyle ilgili güncel yaklaşımları aktarmayı planladık. Daha sonra immunolojik süreçlerin, kronik ağrının periferik ve santral boyutlarıyla olan ilişkilerini<span style="mso-spacerun:yes"> </span>detaylı olarak ele alarak<span style="mso-spacerun:yes"> </span>ağrılı durumlara yol açan mekanizmaları aktarmayı ve halen kullanılmakta olan tedavi seçeneklerine alternatif oluşturabilecek<span style="mso-spacerun:yes"> </span>araştırmalara ışık tutmayı amaçladık. Ayrıca Migrenin ortaya çıkışında<span style="mso-spacerun:yes"> </span>immun sistemin olası etkileri konusundaki bilgileri bu konulara ilgi duyan tüm araştırmacılarla ve öğrencilerle paylaşmak istedik.</span></p><p> <br></p>