Genetic factors associated with the predisposition to late onset Alzheimer's disease
Makaleler > Tam Makale · 2019
Yazarlar: Asude DURMAZ, Dursun Emre KUMRAL, Mehmet Burak DURMAZ, HÜSEYİN ONAY, Gulcin Itirli Aslan, Feriştah Ferda ÖZKINAY, Sacide Pehlivan, Mehmet Nurullah ORMAN, Muhsin Özgür ÇOĞULU
GENE, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2019, cilt 707, ss 212-215
DOI: 10.1016/j.gene.2019.05.030
Özet
Background Alzheimer's disease is a progressive, irreversible neurodegenerative disorder characterized by loss of memory and cognitive skills. More than 90% of cases are sporadic and have later age of onset. Many studies have shown a genetic predisposition for late onset Alzheimer's disease (LOAD). The most studied genetic predisposition factor is apolipoprotein E gene besides other susceptibility genes involved in vascular pathologies, homocysteine metabolism, and neuronal growth and differentiation such as methylenetetrahydrofolate reductase (MTHFR), angiotensin-converting enzyme (ACE), APOB and brain derived neurotrophic factor (BDNF).