Gold nanoparticle/polymer nanocomposite for highly sensitive drug–DNA interaction
Articles > Article · 2015
Authors: FİLİZ KURALAY, Kadriye Arzum ERDEM GÜRSAN
The Analyst, Journal Indexed in SCI Expanded, International, WoS, 2015, vol 140, pp 2876-2880
DOI: 10.1039/c5an00061k
Summary
The interaction of the anticancer drug mitomycin C (MC) and DNA immobilized on gold a nanoparticle/polyvinylferrocenium (AuNP/PVF(+)) coated electrode is presented. This is the first attempt to prepare a biocompatible nanoparticle/redox polymer composite in a one-step and easy electropolymerization procedure and then use the coated electrode for MC-DNA interaction. The prepared electrode exhibits high sensitivity for the investigation of drug-DNA interaction.