Gold nanoparticle polymer nanocomposite for highly sensitive drug DNA interaction
Makaleler > Tam Makale · 2015
Yazarlar: FİLİZ KURALAY, Kadriye Arzum ERDEM GÜRSAN
The Analyst, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2015, cilt 140, ss 2876-2880
DOI: 10.1039/C5AN00061K
Özet
The interaction of the anticancer drug mitomycin C (MC) and DNA immobilized on gold a nanoparticle/polyvinylferrocenium (AuNP/PVF(+)) coated electrode is presented. This is the first attempt to prepare a biocompatible nanoparticle/redox polymer composite in a one-step and easy electropolymerization procedure and then use the coated electrode for MC-DNA interaction. The prepared electrode exhibits high sensitivity for the investigation of drug-DNA interaction.