04 - INVESTIGATION OF IMMUNOLOGICAL PARAMETERS IN THE FIRST EPISODE PSYCHOSIS PATIENTS
Diğer yayınlar > Diğer · 2019
Yazarlar: Talat Sarikavak, Özgür ÖZKALAYCI
Diğer, Uluslararası, 2019,
Özet
Introduction: Schizophrenia and disorders in this spectrum are psychiatric disorders that start at a young age. Current approaches about etiology are that immunologic and autoimmune factors play a role in the etiology and course of the disease. Objectives: This study was planned to investigate the immunologic baseline of first-episode psychosis patients, to determine their association with symptom content and severity, and to identify markers for prognostic-predictive screening.Methods:29 patients with short-term psychotic disorder or schizophreniform disorder according to DSM-IV and 25 healthy controls were studied. Once volunteer approvals were received, SCID-1 structured interview was performed for diagnostic validation, PANSS and BPRS was applied for disease severity. Blood was taken for the immunological parameters to be worked after the interviews.Results:No statistically significant difference was found between the patient and control groups in terms of age, gender, duration of education. Mean total score of PANSS was 97.2 u00b1 11.15 and BPRS score was 49.75 u00b1 13.11. Sensitive CRP, Ferritin, Serum Amyloid A, IgG, IgM, IgA, IgE, C4, Vitamin A, Vitamin E, Anti-Tiroglogulin and Anti Thyroperoxidase were significantly different between the groups. BPRS score were significantly correlated with Copper, Vitamin A and Vitamin E, PANSS Positive Symptoms Sub-Scale score with Serum Amyloid A and Anti Thyroglobulin, PANSS Negative Symptoms Sub-Scale score with Serum Amyloid A and Sensitive CRP. Conclusions:Our study found significant differences in immunological parameters between first-episode psychosis patients and healthy controls.Some of these differences are also correlated with clinical symptoms. Similar studies may reveal relationships with endophenotypes and immunological parameters.