TPH1 A218 allele is associated with suicidal behavior in Turkish population
Articles > Article · 2016
Authors: onur beden, Ender ŞENOL, Sevcan ATAY, Handan AK, AYŞE ENDER ALTINTOPRAK, Güçlü Selahattin KIYAN, Buket Petin, Utku Yaman, Hikmet Hakan AYDIN
LEGAL MEDICINE, Journal Indexed in SCI Expanded, International, 2016, vol 21, pp 15-18
DOI: 10.1016/j.legalmed.2016.05.005
Summary
Background: Serotonergic dysfunction is implicated in depression, psychiatric disorders and suicidal behaviors. The first and rate-limiting step in the synthesis of serotonin is catalyzed by tryptophan hydroxylase (TPH) which is encoded by TPH1 and THP2 genes. Genetic association studies have revealed contradictory results about the effect of the TPH1 A218C (rs1800532) polymorphism on suicidal behavior in different populations.