Synthesis and cholinesterase inhibitory activity of some phenylacetamide derivatives bearing 1H-pyrazole and 1H-1,2,4-triazole
Makaleler > Tam Makale · 2015
Yazarlar: Ayşe Hande TARİKOĞULLARI DOĞAN, Mehmet Murat ÇİZMECİOĞLU, MERVE SAYLAM, Sülünay PARLAR ÇOŞKUN, Vildan ALPTÜZÜN, Zeynep SOYER
MARMARA PHARMACEUTCAL JOURNAL, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Scopus, 2015, cilt 20, ss 21-21
DOI: 10.12991/mpj.2016202105828
Özet
A group of N-phenylacetamide derivatives bearing five \nmembered heterocyclic rings, pyrazole or 1,2,4-triazole, \nwere synthesized to investigate their cholinesterase \ninhibitory activities. Acetylcholinesterase (AChE) and \nbutyrylcholinesterase (BuChE) inhibitory activities were \nevaluated by using Ellman’s spectroscopic method. Results \nindicated that all of the compounds displayed moderate and \nselective AChE inhibitory activity and the most active compound \nwas 2-(1H-1,2,4-triazole-1-yl)-N-(3-methoxyphenyl)acetamide \nwith an IC50 value of 6.68 mM. Docking studies were also carried \nout for the most active compound