Capecitabine maintenance therapy following docetaxel/capecitabine combination treatment in patients with metastatic breast cancer
Makaleler > Tam Makale · 2015
Yazarlar: Zeki Gokhan SURMELI, Umut VAROL, Burcu ÇAKAR, Mustafa DEGIRMENCI, Cagatay Arslan, Gonul Demir PISKIN, Baha ZENGEL, Burcak KARACA, Ulus Ali ŞANLI, RÜÇHAN USLU
Oncology Letters, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2015, cilt 10, ss 2598-2602
DOI: 10.3892/ol.2015.3546
Özet
The present study aimed to analyze the efficacy of maintenance therapy with single agent capecitabine for human epidermal growth factor receptor (HER2) negative metastatic breast cancer (MBC) patients following disease control with 6 cycles of docetaxel plus capecitabine chemotherapy as the first-line treatment. As an initial treatment, 6 cycles of docetaxel plus capecitabine followed by maintenance therapy with capecitabine were administered. A total of 55 patients received combination therapy and 48 patients proceeded to maintenance therapy: Of these, 32 patients (66.7%) were postmenopausal and 37 (77.1%) had estrogen and progesterone receptor positive disease. The median progression-free survival rate with maintenance therapy was 5.5 months (95% CI, 0-11.4 months) and the median overall survival (OS) was 26.6 months (95% CI, 21.8-30.1 months). The use of maintenance therapy improved previous responses in 4 patients (8.3%; 2 partial and 2 complete responses) and 32 patients (66.7%) had stable disease. The median number of maintenance therapy cycles applied was 6.5 (range 1-28, total 441). The observation of side effects, including grade 3/4 neutropenia, febrile neutropenia and fatigue was more common during combination therapy. The results of the present study indicate that maintenance with single agent capecitabine therapy is an effective and tolerable treatment option for HER2 negative MBC patients in which disease control with 6 cycles of docetaxel plus capecitabine chemotherapy is achieved in the first-line setting.