A Retrospective Comparative Study Of Intrinsic Moleculer Breast Cancer Subtypes Between Young And Elderly Women With Breast Cancer.
Bildiriler > Özet Bildiri · 2016
Yazarlar: Gulcan BULUT, Zeki Gokhan SURMELI, Mustafa SAHBAZLAR, Ulus Ali ŞANLI, RÜÇHAN USLU, Bulent Karabulut, Saziye Burcak Karaca
Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Amerika Birleşik Devletleri, Uluslararası, Sözlü Sunum, Özet Bildiri, 2016-2016, Wos, cilt 34, ss e12063-e12063
DOI: 10.1200/jco.2016.34.15_suppl.e12063
Özet
e12063 Background: Age is an important prognostic factor in breast cancer. Both younger and older patients have a higher risk of mortality. In this study we examined the intrinsic breast cancer subtypes and survival outcomes in breast cancer patients aged < 35 years > 75 years. Methods: Medical records of patients with breast cancer who were aged < 35 or > 75 years at diagnosis were retrospectively reviewed. Intrinsic breast cancer subtypes were determined in accordance with St. Gallen surrogate molecular subtype definitions. Results: 212 patients aged < 35 and 75 patients aged > 75 were included. Median age was 33.2 (range 21 – 34.9) in the younger group and 77.8 (range 75 – 88.1) in the older group. 9.4% of younger group and 18.3% of older patients were metastatic at diagnosis (p:0.04). T3 or T4 tumors were present in 19.8% and 10% of patients in younger and older patients, respectively (p:0.078). N2/N3 disease was present in 45% of younger and 50.8% of older groups. Luminal A was the most common subtype (40.5%) in the older group, whereas luminal B was the most common subtype (50.6%) in the younger group (p: < 0.001). Frequency of HER2 positive (11.1% in younger vs. 17.6% in older) and triple-negative subtypes (21% in younger vs. 13.5% in older) were not significantly different. In both younger and older groups, breast cancer specific survival was superior in luminal (A+B) subtype compared to HER2 positive and triple-negative subtypes. Conclusions: Breast cancer subtype frequencies differ between younger ( < 35 years) and older ( > 75 years) patients. The most common subtypes are luminal A in older patients and luminal B in younger patients. For both older and younger patients, breast cancer subtypes have an important prognostic impact