Preparation of magnetic gelatin nanoparticles and investigating the possible use as chemotherapeutic agent
Articles > Article · 2013
Authors: Habibe Yilmaz, Şenay ŞANLIER
Artificial Cells, Nanomedicine, and Biotechnology, Journal Indexed in SCI Expanded, International, Scopus, 2013, vol 41, pp 69-77
DOI: 10.3109/21691401.2012.745863
Summary
Iron oxide nanoparticles coated with gelatin trough two-step desolvation method and characterized. SEM analyse showed that the nanoparticles are spherical and TEM image showed that the iron oxide nanoparticles encapsulated with gelatin. Also FTIR, TG and magnetization analyses exhibited that iron oxide nanoparticles encapsulated as well. Drug loading by adsorption studied under various conditions as different temperature, contact time and initial cisplatin concentration. Also, Langmuir, Freundlich and Dubinin-Raduskevich adsorption isotherm curves were constracted and constants were calculated. In vitro drug release was performed at pH 5 and 7.4 and hyperthermic drug release investigated at 42°C and compared with non-hyperthermic drug release.