Correlation between single nucleotide polymorphisms in TLR4, LTA and RFP175 genes and susceptibility to invasive bacterial infections in infants under three months of age: A case control study
Makaleler > Tam Makale · 2025
Yazarlar: Ali YURTSEVEN, Enise AVCI DURMUŞALİOĞLU, Benay Turan, Eylem Ulaş SAZ
Pakistan Journal of Medical Sciences, Uluslararası, Wos, 2025, cilt 41, ss 3498-3502
DOI: 10.12669/pjms.41.12.12651
Özet
Objective: This study investigates the correlation of TLR4 rs2149356, LTA rs2229094 and RFP175 rs1585110 genes single nucleotide polymorphisms (SNPs) with invasive bacterial infections (IBIs) in neonates and young infants. Methodology: We conducted a prospective, case-control study at Ege University Faculty of Medicine, Izmir, Turkiye, between January 2021 to December 2023. Infants under 90 days of age admitted with confirmed IBIs (cases) or non-infectious conditions (controls) were included. Genomic DNA was extracted from peripheral blood samples and next-generation sequencing was used to analyze selected SNPs in TLR4, LTA and RFP175 genes. Clinical and demographic characteristics, as well as SNP frequencies, were compared between groups. Results: A total of 200 infants were enrolled (100 cases, 100 controls). Most infections were urinary tract infections (n=84), 84%), with smaller numbers of gastroenteritis (n=6, 6%), bacteremia (n=5, 5%), pneumonia (n=3, 3%), and meningitis (n=2, 2%). No significant differences were found in clinical characteristics or SNP frequencies between groups. Conclusions: NCT06985160.