Lithium and anticholinergic combination to maintain a stable lithium plasma level
Articles > Article · 1994
Authors: S. Eralp Bellibas, Sibel Ülker, Kazim Akfert, Isik Tuglular, Simavi VAHİP
Human Psychopharmacology: Clinical and Experimental, International, 1994, vol 9, pp 33-36
Summary
Abstract The effect of lithium and propantheline, an anticholinergic agent, combination on plasma and red blood cell (RBC) lithium levels was studied to test if this combination could maintain a stable plasma lithium level for a long‐lasting period by delaying gastric emptying, in rabbits. There was a significant difference in plasma lithium levels between control and propantheline‐administered groups (p < 0·01). The peak level seen in the second hour of lithium administration in the control group was not observed in the propantheline‐administered group and a stable lithium level was maintained. It was suggested that a lithium and anticholinergic drug combination can be an alternative in eliminating the peak plasma levels of lithium and preventing the side‐effects thought to be related to this factor.