P-202THE PROGNOSTIC VALUE OF CARCINOEMBRYONIC ANTIGEN LEVELS IN THE BLOOD AND INTRAOPERATIVE PLEURAL LAVAGE FLUID IN NON-SMALL CELL LUNG CANCER
Makaleler > Tam Makale · 2016
Yazarlar: Tevfik İlker AKÇAM, Ufuk ÇAĞIRICI, Ali ÖZDİL, Ayşe Gül ERGÖNÜL, K. Turhan, Alpaslan ÇAKAN
Interactive CardioVascular and Thoracic Surgery, Uluslararası, Wos, 2016, cilt 23, ss i54.3-i54
Özet
Objectives: There is no specific marker for lung cancer but in some lung cancer types carcinoembryonic antigen (CEA) can reach high levels in the blood and pleural fluid. In this study the relationship between CEA levels in blood (CEAB) and intraoperative pleural lavage fluid (CEAP) in non-small cell lung cancer (NSCLC) and the type, stage, extent of lung cancer was investigated. Methods: A total of 50 patients who underwent surgery at our clinic for NSCLC (Group I) and benign lung pathology (Group II) were assessed. For this prospectively designed study, 25 consecutive patients were included in each group and their CEAB and CEAP levels were investigated. Results: When the CEAB levels were measured, the average value was 14.13 ng/ml (0.77-139.3) and 1.70 ng/ml (0.54-3.42) in Group I and II, respectively (P < 0.05). When the levels of CEAP were compared, the average value of Group I (1.35 ng/ml), was significantly higher than the average value of Group II (0.04 ng/ml) (P = 0.027). When CEA levels were examined separately and average values were taken according to surgical pathology results both CEAB and CEAP levels of the patients with adenocarcinoma diagnosis were found to be higher than the other groups. It was detected that this difference was only significant for the level of CEAP (P = 0.026). Conclusion: Although the average CEAB levels of patients with adenocarcinoma were higher than other histopathological types, this difference was not statistically significant. However, we found that CEAP levels were significantly high in patients with adenocarcinoma. These results have led us to consider that CEAP elevation is more sensitive than the blood level. Also, it indicated that it is necessary to examine CEAP levels even if the CEAB level of the patient was low. Disclosure: No significant relationships.