Determination of the Gene Expression Profiles of JAK/STAT Cascade Components for the Potential Role of Capsaicin Induced Apoptosis of Acute T-Cell Lymphoblastic Leukemia Cells
Makaleler > Tam Makale · 2013
Yazarlar: Burçin KAYMAZ, Vildan BOZOK, Buket KOSOVA
Kafkas Journal of Medical Sciences, Diğer Kurumların Hakemli Dergileri, Uluslararası, TR Dizin (Ulakbim), 2013, cilt 3, ss 129-135
Özet
AIM: Capsaicin, an ingredient of red chili pepper consumed as spice throughout the world is defi ned as "double-edged sword" agent for having possible tumorigenicity/genotoxicity properties, for being antagonist to carcinogens/mutagens for inducing tumor cell apoptosis.However, reasons of capsaicin induced leukemic cell apoptosis are investigated.In this study, following capsaicin treatment to acute lymphoblastic leukemia cell line CCRF-CEM, detecting apoptosis; determining gene expression profi les of JAK/STAT signaling pathway members STAT3, STAT5A,-5B, JAK2,IL-6 mRNA levels and clarifying possible molecular effect mechanism of capsaicin were aimed.