Effects of Lycium barbarum on bacterial translocation in thioacetamide-induced liver injury in rats
Makaleler > Tam Makale · 2015
Yazarlar: Y Bilgic, MMM Harputluoglu, Özben KUTLU, U Demirel, M Gul, B Otlu, I Temel, S Gursoy, R Dertli, EB Selcuk, I Yilmaz, T Kilis
European Journal of Inflammation, Uluslararası, 2015, cilt 13, ss 154-163
Özet
Background and study aim: The aim of the present study was to investigate the effects of Lycium barbarum (LB) on bacterial translocation (BT) frequency in thioacetamide (TAA)-induced liver injury in rats. Materials and methods: Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days. In group 3 (TAA+LB), Lycium barbarum was administered orally 25 mg/kg for 21 days prior to the first TAA injection. In group 4 (LB), rats received only Lycium barbarum. Results: In our study, Lycium barbarum treatment did not attenuate liver damage. Lycium barbarum treatment decreased ileal E. coli counts and intestinal damage but it did not alter BT frequency. Conclusions: In conclusion, the effects of Lycium barbarum on BT may be related to ongoing severe liver damage in this model.