Paraoxonase and acetylcholinesterase activities in humans exposed to organophosphorous compounds
Conference paper > Full Text
Authors: Serap Annette AKGÜR, P. Ozturk, Eser YILDIRIM SÖZMEN, Yasemin AKÇAY, T. Tanyalcin, B. Ege
, International, Full Text, vol 43, pp 11-17
Summary
Organophoshorous compounds (OP) are used as pesticides in Turkish agriculture. OP inhibit acetylcholinesterase (AchE) activities on the other hand serum paraoxonase (PON1) hydrolyzes the toxic metabolites of a variety of OP. AChE and PON1 activities in serum were measured spectrophotometrically. The individuals were classified for PON1 phenotypes as A, AB and B types. A positive correlation was found between AChE activities and percent of PON1 stimulation. This study suggests that individuals with phenotype A might be more sensitive to OP induced toxicity.