Diuretic effect of frusemide in patients with nephrotic syndrome: is it potentiated by intravenous albumin?
Articles > Article · 1995
Authors: F AKCICEK, T YALNIZ, ALİ BAŞCI, Ercan OK, EJD MEES
BMJ, Journal Indexed in SCI Expanded, International, 1995, vol 310, pp 162-163
Summary
We investigated the claim that infusion of albumin potentiates the diuretic effect of frusemide in patients with the nephrotic syndrome.1 We selected 12 inpatients with the nephrotic syndrome according to two criteria: (a) failure to lose weight after bed rest and a 40 mmol sodium diet and (b) presence of minimal lesions or a well preserved glomerular histology on renal biopsy. We gave each patient three treatments randomly from 8 am to noon, at intervals of at least two days—infusion of albumin 0.5 g/kg given as a 20% solution for four hours; infusion of frusemide 60 mg bolus followed by 40 mg/h for four hours; and a combined treatment of both types of infusion. We collected urine on the treatment days from 8 am to 2 pm and …