Efficacy of zoledronic acid treatment in Paget disease of bone
Bildiriler > Özet Bildiri
Yazarlar: Emine Kartal Baykan, Lütfiye Füsun SAYGILI, Mehmet Erdogan, A Gokhan Ozgen, Şevki ÇETİNKALP, Candeger Yilmaz
Endocrine Abstracts, , , Uluslararası, Özet Bildiri
Özet
Purpose: Paget disease is a disease of bone of unknown etiology with increased bone turnover that results in defective bone microarchitecture and bone deformity.Bisphosphonates are used in symptomatic Paget disease of bone.Clinical trials have shown that zoledronic acid was more effective than other bisphosphonates in treatment of Paget disease. Methods:In this study, we retrospectively reviewed the remission and relapse statuses of 12 patients with Paget disease of bone, who were seen as outpatients between October 2011 and October 2013.We evaluated alkaline phosphates, osteocalcin, deoxypyridinoline levels measured before and at 6 th, 12 th,18th months of treatment.Results: Pretreatment and post-treatment valus for alkaline phosphates, deoxypyridinoline, osteocalcin were as follows; 473 ± 256 U/L, 14.99 ± 7.63 mmol/L, 21.09 ± 3.18 ng/ml and 82 ± 13 U/L, 5.14 ± 1.11 mmol/L, 8.57 ± 4.31 ng/ml.Remission was achieved in all patients after treatment.The levels indicated remission continued at 12th and 18th months of treatment.There was statistically significant difference between pretreatment and post-treatment values.No statistically significant difference between the levels measured at 6th, 12th and 18th months of treatment were detected. Conclusion:We recommend zoledronic acid in the first line treatment of Paget disease of bone in achieving and maintaining remission.