Microbial transformation of Astragalus sapogenins using Cunninghamella blakesleeana NRRL 1369 and Glomerella fusarioides ATCC 9552
Articles > Article · 2015
Authors: ERDAL BEDİR, CEYDA KULA, Ozlem Oner, Melis ALTAS, Ozgur TAĞ, Gaye ÖNGEN ÖZGEN
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, Journal Indexed in SCI Expanded, International, 2015, vol 115, pp 29-34
DOI: 10.1016/j.molcatb.2015.01.013
Summary
The microbial transformation of Astragalus sp. derived sapogenins, namely cycloastragenol, astragenol and cyclocanthogenol, by Cunninghamella blakesleeana NRRL 1369 and Glomerella fusarioides ATCC 9552 were investigated. The unique enzyme system of both fungi resulted hydroxylation, cyclization, dehydrogenation and oxidation reactions. Structures of the new metabolites were elucidated by 1-D (H-1, C-13, NOESY), 2-D NMR (DQF-COSY, HMBC, HMQC, NOESY) and HR-MS analyses. (C) 2015 Elsevier B.V. All rights reserved.