Microbial transformation of Astragalus sapogenins using Cunninghamella blakesleeana NRRL 1369 and Glomerella fusarioides ATCC 9552
Makaleler > Tam Makale · 2015
Yazarlar: ERDAL BEDİR, CEYDA KULA, Ozlem Oner, Melis ALTAS, Ozgur TAĞ, Gaye ÖNGEN ÖZGEN
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2015, cilt 115, ss 29-34
DOI: 10.1016/j.molcatb.2015.01.013
Özet
The microbial transformation of Astragalus sp. derived sapogenins, namely cycloastragenol, astragenol and cyclocanthogenol, by Cunninghamella blakesleeana NRRL 1369 and Glomerella fusarioides ATCC 9552 were investigated. The unique enzyme system of both fungi resulted hydroxylation, cyclization, dehydrogenation and oxidation reactions. Structures of the new metabolites were elucidated by 1-D (H-1, C-13, NOESY), 2-D NMR (DQF-COSY, HMBC, HMQC, NOESY) and HR-MS analyses. (C) 2015 Elsevier B.V. All rights reserved.