Community acquired bacteremia in older adults: International and prospective infectious diseases-international research initiative (ID-IRI) study
Makaleler > Tam Makale · 2026
Yazarlar: Sevgi Sokulmez-Yildirim, Hakan Erdem, Handan Ankarali, Seniha Senbayrak, Elif Doyuk Kartal, Ozlem Bayrak, Aruna Poojary, Ilad Alavi Darazam, Beyza Sullu, Meltem Tasbakan, Refika Nur Kahraman, Halime Araz, Pinar Yuruk Atasoy, Tatjana Roganovic, Sinan Cetin, Dilek Yekenkurul, Rok Civljak, Zeynep Oktay, Ahmet Dogan, Gulay Okay, Ergys Ramosaco, Abdullah Umut Pekok, Rukiye Inan-Sarikaya, Egidia Miftode, Entela Kolovani, Fatma Amer, Firdevs Aksoy, Homa Ghasempour, Larisa Miftode, Gergana Lengerova, Amani El-Kholy, Svjetlana Grgic, Michael Mihailov Petrov, Sevil Alkan, Stanislav Kotsev, Maria Pishmisheva Peleva, Bahar Busra Sivrikaya, Davut Ipek, Kostadin Poposki, Massimiliano Lanzafame, Oznur Ak, Selcuk Yaylaci, Mustafa Altindis, Arzu Cennet Isik, Belgin Coskun, Esra Gurbuz, Ghaydaa A. Shehata, Nilgun Koltuk Kaya, Ilkay Bozkurt, Ayfer Imre, Ayse Sagmak Tartar, Cigdem Yildirim, Irina Magdalena Dumitru, Luca Mihaela Catalina, Maya Belitova, Omnia Mohamed Elnabawy Ahmed Taher, Sema Sari, Antonio Cascio, Bilal Ahmad Rahimi, Gulden Eser Karlidag, Maria Ioana Onofrei, Sevda Ozdemir Al, Sholpan Kulzhanova, Yasemin Cag, Hatice Kubra Ucar, Cumhur Ozmen, George Sebastian Gherlan, Maha Ali Gad, Nasim Akhtar, Serkan Oncu, Tarsila Vieceli, Aidos Konkayev, Aliye Esmaoglu, Asli Kilavuz, Pinar Sirmatel Bucuk, Balint Gergely Szabo, Christian Gomez Davila, Cihan Semet, Edmond Puca, Emine Unal Evren, Hamed Azhdari Tehrani, Kumar Angamuthu, Meliha Cagla Sonmezer, Orcun Soysal, Selma Ates, Giulia Spurio, Sultan Keskin Demircan, Taylan Onder, Fevzi Coskun Sökmen, Jordi Rello, Anna Giammanco, Teresa Fasciana
International Journal of Infectious Diseases, Uluslararası, Wos, 2026, cilt 169, ss 108767-108767
DOI: 10.1016/j.ijid.2026.108767
Özet
OBJECTIVES: Community-acquired bloodstream infections (CA-BSIs) are a major cause of mortality in older adults, yet prospective international data are limited. This study evaluated clinical features, microbiology, and mortality predictors in older patients with CA-BSI. METHODS: This prospective, observational study was conducted in 72 referral centers across 16 countries between June 1 and September 1, 2024. Patients aged ≥65 years with confirmed CA-BSI were included. Demographic, clinical, laboratory, and treatment data were collected. The primary outcome was 30-day all-cause mortality. Univariate and multivariate logistic regression was used to identify predictors. RESULTS: 574 patients were enrolled (median age 74 years; 48.1% female), and 30-day mortality was 26.3%. Urinary tract infection was the most common source (33.7%), and 30.5% had no identifiable origin. Gram-negative organisms predominated (58.6%). Independent mortality predictors included SOFA score ≥5, thrombocytopenia (<50,000/µL), Staphylococcus aureus bacteremia, pneumonia, bacteremia of unknown origin, and higher Charlson Comorbidity Index. Higher Katz Activities of Daily Living scores were protective. CONCLUSION: CA-BSI in older adults is associated with high mortality. Outcomes are driven by comorbidity burden, functional status, infection severity, and causative pathogen, highlighting the need for early risk stratification and tailored management.