Enhancing Radiotherapy Tolerance With Papaya Seed‐Derived Nanoemulsions
Makaleler > Tam Makale · 2025
Yazarlar: Muhammad Tariq Siddiqui, Bilge Olceroglu, Zinar Pınar GÜMÜŞ, Ahmet Murat Senisik, Firat Baris Barlas
Food Science & Nutrition, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2025, cilt 13, ss e70145-e70145
DOI: 10.1002/fsn3.70145
Özet
ABSTRACT Flavonoid‐rich plant materials have gained attention for their potential to reduce radiotherapy side effects. Carica papaya (CP) seeds, known for high flavonoid content, hold promise for therapeutic applications. This study explored the extraction and evaluation of two oils—sunflower oil‐based papaya oil (SPO) and pure papaya oil (PPO)—and their nano emulsions (SPOE and PPOE), derived from CP seeds, for radioprotective effects. Chemical analysis using QTOF‐MS revealed antioxidants and phytochemicals in the oils and emulsions. Size analysis and zeta potential measurements using dynamic light scattering (DLS) showed particle sizes of 140 ± 26.06 nm for PPOE and 293.7 ± 49.42 nm for SPOE. Post‐radiation, both SPOE and PPOE significantly enhanced cell viability, with values of 72.24 ± 3.92 ( p ≤ 0.001) and 75.85 ± 2.62 ( p ≤ 0.001), respectively. These nanoemulsions show potential as topical agents for reducing radiation‐induced tissue damage in radiotherapy. Despite the promising in vitro findings, further in vivo studies are needed to confirm the clinical relevance of these nanoemulsions. Additionally, their incorporation into sunscreen formulations could provide further protection against radiation‐induced skin damage, broadening their potential applications.