Progressive Multifocal Leukoencephalopathy in a Case Without Clear Evidence of Immunodeficiency
Makaleler > Tam Makale · 2012
Yazarlar: Ayşe GÜLER, Figen GÖKÇAY, Damla İŞMAN HAZNEDAROĞLU, Ahmet GÖKÇAY, AYŞIN ZEYTİNOĞLU TÜRKEŞ, Ayse Kocaman SAGDUYU, Hadiye ŞİRİN
JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2012, cilt 29, ss 640-644
Özet
Introduction: Progressive Multifocal Leukoencephalopathy(PML) is a rare demyelinating disease of the central nervous system due to reactivation of a latent infection with JC papovavirus. PML predominantly occurs in severely immunosupressed patients, mostly as a late complication of acquired immunodeficiency syndrome and lymphoproliferative disorders. Clinically it is manifested by motor and sensory deficits, ataxia, cognitive impairment and dementia, corresponding to central nervous system (CNS) lesions. It is difficult to distinguish PML clinically from immune-mediated diseases of the CNS, such as multiple sclerosis, neuropsychiatric sistemic lupus erythematosus and CNS vasculitis.