Reference values for mean overnight saturation in sleep apnoea – the European Sleep Apnoea Database (ESADA)
Bildiriler > Özet Bildiri
Yazarlar: Ludger Grote, Holger Hein, Özen KAÇMAZ BAŞOĞLU, Ondrej Ludka, Johan Verbraecken, Athanasia Pataka, Stefan Mihaicuta, Pawel Sliwinski, Tarja Saaresranta, Marisa Bonsignore, Ding Zou, Jan Hedner
Sleep and control of breathing, , , Uluslararası, Özet Bildiri, ss 4996-4996
DOI: 10.1183/13993003.congress-2020.4996
Özet
Introduction: Normative values for mean overnight oxygen saturation during sleep in apnoea patients stratified for age, BMI, and sleep apnoea severity are lacking. Aim: To establish reference intervals for overnight mean saturation in a large sleep apnoea patient cohort. Methods: Mean overnight oxygen saturation was analysed in adult patients (n=23,220) from the European Sleep Apnoea Database (ESADA, 30 sleep centres, 18 European countries). Data were classified according to age, gender, BMI (<25, 25-<30, 30-<35, ≥35 kg/m2), apnoea hypopnea index (<5, 5-<15, 15-<30, ≥30 n/h), and comorbidities like pulmonary disease, heart failure, hypertension, and current smoking. Reference intervals for mean overnight oxygen saturation were calculated. A generalised linear model was applied to determine the independent contribution of these factors on mean saturation. Results: Mean overnight saturation was 93.0% (95% confidence interval (CI) 92.9 to 93.1%). Age influenced the adjusted mean nocturnal saturation (93.6%, 93.2%, 92.9%, 92.5%, 92.2% and 91.9% for those aged 18-29, 30-39, 40-49, 50-59, 60-69, and ≥70 years, respectively) p<0.0001. Morbid obesity reduced the saturation level by 2.7% (CI 2.5-2.9), p<0.001. Current smoking was associated with a reduction of mean saturation by 0.6% (CI 0.5-0.7%), p<0.001. Finally, severe OSA decreased mean saturation during sleep (2.3% (CI 2.1-2.4)), p<0.001. Conclusion: This study in a large, multi-centric European sleep apnoea cohort defined reference intervals for mean overnight saturation stratified for important confounders like age, BMI, and smoking. Our findings are applicable to the general practice of sleep medicine.