Synthesis of novel Schiff base ligands from gluco- and galactochloraloses for the Cu(II) catalyzed asymmetric Henry reaction
Makaleler > Tam Makale · 2015
Yazarlar: Sevda ALKAN, Fatma TELLİ, Azize Yeşim SALMAN, Stephen Thomas ASTLEY
CARBOHYDRATE RESEARCH, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2015, cilt 407, ss 97-103
DOI: 10.1016/j.carres.2015.01.023
Özet
A series of chiral Schiff base ligands has been prepared using aminochloralose derivatives of glucose and galactose. These ligands were used as catalysts in the asymmetric Henry reaction in the presence of Cu(II) ions giving yields of up to 95%. An interesting solvent dependency on enantiomeric control was observed with the best enantiomeric excesses (up to 91%) being obtained in the presence of water. (C) 2015 Elsevier Ltd. All rights reserved.