A heterodimeric [RGD-Glu-[64Cu-NO2A]-6-Ahx-RM2] αvβ3/GRPr-targeting antagonist radiotracer for PET imaging of prostate tumors
Articles > Article · 2013
Authors: Kübra TOPALOĞLU, Zongrun JIANG, Tammy L. ROLD, Gary L. SIECKMAN, Timothy J. HOFFMAN, Rajendra Prasad BANDARI, Ashley F. SZCZODROSKI, Liqin Liu, Yubin Miao, Tamila Stott REYNOLDS, Charles J. SMITH
Nuclear Medicine and Biology, Journal Indexed in SCI Expanded, International, WoS, 2013, vol 41, pp 133-139
DOI: 10.1016/j.nucmedbio.2013.11.006
Summary
Introduction: In the present study, we describe a Cu-64-radiolabeled heterodimeric peptide conjugate for dual alpha(v)beta(3)/GRPr (alpha(v)beta(3) integrin/gastrin releasing peptide receptor) targeting of the form [RGD-Glu-[Cu-64-NO2A]-6-Ahx-RM2] (RGD: the amino acid sequence [Arg-Gly-Asp], a nonregulatory peptide used for alpha(v)beta(3) integrin receptor targeting; Glu: glutamic acid; NO2A: 1,4,7-triazacyclononane-1,4-diacetic acid; 6-Ahx: 6-amino hexanoic acid; and RM2: (D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2), an antagonist analogue of bombesin (BBN) peptide used for GRPr targeting).