Radiation-induced meningiomas following childhood cranial radiotherapy—report of four cases
Makaleler > Tam Makale · 2025
Yazarlar: Larisa Andrada AY, Erkin ÖZGİRAY, Nevhis AKINTÜRK, Emine Serra KAMER, Yeşim ERTAN
Egyptian Journal of Neurosurgery, ESCI İndekslerine Giren Dergi, Uluslararası, Emerging Sources Citation Index (ESCI), 2025, cilt 40, ss 1-10
DOI: 10.1186/s41984-025-00373-1
Özet
Abstract Background Radiation-induced meningiomas represent a late side effect of cranial radiation therapy. The most widely used diagnostic criteria, despite the lack of a standard description, is a meningioma that develops in a previously irradiated area following a predetermined time interval. Case presentation We present four cases of late-onset cranial atypical meningiomas following childhood cranial radiotherapy. Four patients (two females and two males) between 4 and 13 years of age at the time of cranial irradiation developed secondary intracranial meningioma after a latency period of 8–34 years. Surgical resection of the tumors was performed, and histopathological examination revealed a diagnosis of atypical meningioma in all four patients. Conclusion Radiation-induced tumors continue to be a significant side effect of radiotherapy and radiosurgery, and they are frequently identified as recurrent, numerous, and more aggressive. Prolonged follow-up should definitely not be ignored in patients with antecedents of radiotherapy for a primary cerebral tumor or cranial irradiation for an early age malignancy.