Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with experimentally induced sepsis
Articles > Article · 2013
Authors: Oytun ERBAS, Ahmet Mete ERGENOĞLU, Ali AKDEMİR, Ahmet Özgür YENİEL, Dilek TAŞKIRAN
JOURNAL OF SURGICAL RESEARCH, Journal Indexed in SCI Expanded, International, 2013, vol 183, pp 313-320
DOI: 10.1016/j.jss.2012.11.043
Summary
Background: Critical illness polyneuropathy is an acute neuromuscular disorder of critically ill patients and is characterized by limb and respiratory muscle weakness. The purpose of the study was to evaluate the neuroprotective effects of melatonin (MEL) and oxytocin (OT) on the early stage of sepsis by recording compound muscle action potentials and measuring plasma tumor necrosis factor (TNF)-alpha levels, lipid peroxidation (malondialdehyde; MDA), and total antioxidant capacity.