Synthesis of Stable Acyclic Aminals Derived from L-(+)-Aspartic Acid and Their Application in Asymmetric Henry Reactions
Makaleler > Tam Makale · 2013
Yazarlar: Gamze Koz, Demet ASTLEY, Stephen Thomas ASTLEY
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2013, cilt 68, ss 57-63
Özet
A series of stable acyclic aminals derived from L-(+)-aspartic acid were synthesized in excellent yields (up to 96%) and characterized by spectroscopic methods. They were applied as enantioselective catalysts in Henry reactions of nitromethane with various aldehydes in the presence of Cu(II) ions, affording the corresponding adducts in high yields (up to 90%) and enantioselectivities (up to 92% ee).