Liquid Crystals, Rasagiline mesylate, Glyceryl Monooleate, Parkinson, Buccal delivery
Makaleler > Tam Makale · 2024
Yazarlar: Meliha GÜNEŞ, Gökçe TURAN, Özgür MASALCI, Kevser Özgen ÖZER, Sinem Yaprak KARAVANA
Hacettepe University Journal of the Faculty of Pharmacy, Hakemli Üniversite Dergisi, Uluslararası, Scopus, 2024, cilt July 2024, ss 46-52
DOI: https://doi.org/10.52794/hujpharm.1420721
Özet
<p>The morning “off period” in individuals with Parkinson’s disease (PD), characterized by challenges in receiving the appropriate dose for sleep, insufficient drug levels in the blood, and gastrointestinal issues, poses a significant challenge that impacts the overall quality of life for these patients. Based on research findings, these issues can be successfully addressed using non-oral treatments exclusively. Numerous mucoadhesive systems, such as lyotropic liquid crystals (LCs), have been identified[1–4]. These systems can form an oblique connection with the buccal mucosa, thereby extending the residence time and optimizing drug bioavailability. The objective of this study is to prepare rasagiline mesylate (RM), glyceryl monooleate/poloxamer 188 liquid crystal matrices (GMO/Plx188 LCs) to improve the bioavailability of RM. The structures of the prepared formulations were examined by polarized light microscopy and SAXS analyzed. These formulations were also evaluated for several parameter such as appearance, visualization, content uniformity, homogenity, viscosity, mucoadhesion. Obtained results demonstrates the prospective of liquid crytals as a viable and alternative approach for effective RM buccal delivery.</p>