Synthesis of some 2(3H)-benzoxazolone derivatives and their in-vitro effects on human leukocyte myeloperoxidase activity
Makaleler > Tam Makale · 2005
Yazarlar: Zeynep SOYER, MERAL BAS, Nefise Aysun PABUÇÇUOĞLU, Mehmet Varol PABUÇÇUOĞLU
ARCHIV DER PHARMAZIE, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2005, cilt 338, ss 405-410
Özet
Myeloperoxidase (MPO), a heme protein expressed by polymorphonuclear leukocytes, generates potent oxidants which are proposed to contribute to tissue damage during inflammation and certain pathogenesis such as neurodegenerative disorders. In this study, twenty omega-[2-oxo-3H-benzoxazol-3-yl]-N-phenylacetamide and propionamide derivatives having substituents of different lipophilic and electronic nature on the N-phenyl ring were synthesized to evaluate the inhibitory effects on in vitro leukocyte MPO chlorinating activity. The most active compounds in the series were the derivatives bearing 2-methyl and 4-nitro substituent on the N-phenyl ring.