Otolog periferik kan kök hücre transplantasyonu sonrası mobilizasyon başarı oranı
Makaleler > Tam Makale · 2018
Yazarlar: Demet Çekdemir, Fergun Yilmaz, Fatma Ozsan, Nur SOYER, Bahar Arik, Sevgi Mir, Murat Tombuloglu, Ayhan DÖNMEZ
Sakarya Medical Journal, Uluslararası, 2018
DOI: 10.31832/smj.423989
Özet
Aim: If there issuccessful mobilization following a conditioning regimen forstem cell transplantation, the in vivo purged stem cell products may be collected for a second transplantation. Materials and Methods: In this prospective study, peripheral blood CD34+ cells were quantified between 6 th day after stem cell infusion and 3 rd day after neutrophil engraftment in 20 patients using flow cytometry. Results: In the autologous peripheral blood stem cell transplantation (auto-PBSCT)group(n= 16), the CD34+ cell count was lowest during the first 10 days. The median CD34+ cell count began to increase at the 11 th day and the highest value was achieved at the 14 th day. We documented evidence of mobilization in only one patient (6.25%). Conclusion: Our results indicate thatthe rate of successful stem cell mobilization is very lowfollowing auto-PBSCT. In conclusion, collecting CD34+ stem cells following the first auto-PBSCT is not an effective method for tandem transplantation.