Biological affinity evaluation of Lawsonia inermis origin Lawsone compound and its radioiodinated form via in vitro methods
Articles > Article · 2014
Authors: Volkan TEKİN, Fazilet Zümrüt BİBER MÜFTÜLER, Özge KOZGUŞ GÜLDÜ, Ayfer YURT KILÇAR, Emin İlker MEDİNE, Murat YAVUZ, Perihan ÜNAK, Suna TİMUR
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, Journal Indexed in SCI Expanded, International, 2014, vol 303, pp 701-708
DOI: 10.1007/s10967-014-3435-0
Summary
WST-1-based cytotoxicity assay of lawsone (LW) was performed on MCF7, Caco2, BJ and Keratinocyte cells and viabilities were found as over 90 % for all cells. Significant wound healing effect of LW was reported on Keratinocyte cells. Antibacterial and antifungal activities of LW were tested on seven microorganisms with three concentrations and 1,000 A mu g/disc of LW showed antibacterial effect on Bacillus subtilis. In vitro cell incorporation of radioiodinated LW (I-131-LW) was evaluated on same cells. Keratinocyte cells uptake were 5 times more. Consequently, I-131-LW was found usable for researches about especially skin diseases in addition to breast and intestinal cancer.