AT-101 acts as anti-proliferative and hormone suppressive agent in mouse pituitary corticotroph tumor cells
Makaleler > Tam Makale · 2017
Yazarlar: Banu Pınar ŞARER YÜREKLİ, Betül KARACA, A. Kisim, E. Bozkurt, H. Atmaca, Şevki ÇETİNKALP, G. OZGEN, CENGİZ YILMAZ, S. Uzunoglu, RÜÇHAN USLU, Lütfiye Füsun SAYGILI
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2017, cilt 41, ss 233-240
DOI: 10.1007/s40618-017-0733-8
Özet
Purpose Gossypol, a naturally occurring compound in cottonseeds, has anticancer effects against several tumor cell lines. It has been extensively studied in clinical trials and is well tolerated with a favorable safety profile. AT-101, a derivative of R (-)-gossypol, binds to Bcl-2 family proteins and induces apoptosis in vitro. Although transsphenoidal surgical excision of the pituitary corticotroph adenoma is the gold standard of care, it is not successful all the time. Medical therapy for Cushing's disease still remains a challenge for the clinicians. We aimed to investigate the cytotoxic and apoptotic effects of AT-101 in mouse pituitary corticotroph tumor AtT20 cells.