Tek Doz Kas İçi Trombositten Zengin Plazma Yönteminin Egzersiz Kaynaklı Kas Hasarında Toparlanmaya Etkisi
Bildiriler > Özet Bildiri · 2016
Yazarlar: Zekine Pündük, Hayrettin Kara, Şahver Ege Hişmioğulları, Gökhan Meriç, Onur ORAL, Adnan Adil Hişmioğulları
14th INTERNATIONAL SPORT SCIENCE CONGRESS, Türkiye, Antalya, Uluslararası, Poster, Özet Bildiri, 2016-2016, ss 561-561
Özet
<p>Platelet rich plasma (PRP) therapy is widely used in enhancing the recovery of skeletal muscle from injury. The aim of the study was to investigate the effects of intramuscular delivery of PRP on hematological, biochemical responses, growth factors and recovery strategy by exercise-induced muscle damage (EIMD). Twelve moderately active male volunteers participated in this study and they were randomly divided into two groups; PRP-administrated group (PRP group, n: 6) and control group (n: 6). The volunteers performed an exercise with a load of 80% one repetition maximum (1RM) maximal voluntary contraction of the elbow flexors until point of exhaustion of the non-dominant arm was reached. The arms were treated with saline or PRP post-24 h EIMD. The venous blood samples were obtained in the morning to establish a baseline value and also 1-4 days post-exercise and were analysed for biochemical parameters. Acute exhaustive exercise resulted in increasing muscle damage markers as a creatinine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and alanine aminotransferase (ALT), plasma iron, iron binding capacity (IBC), ferritin, and hepcidin levels. These result indicated that muscle damage induced by exercise (p˂0.01). However, PRP-administration suppressed the increased levels of the serum iron and hepcidin whereas increased IBC level due to muscle damage 2-3 days post-exercise (p˂0.001). Following the exercise (24 h), the levels of plasma insulin-like growth factor (IGF-1), growth hormone (GH) and insulin-like growth factor-binding protein 3 (IGFBP-3) were increased in control group (p˂0.05, p˂0.001, p˂0.001 respectively). PRP increased platelet-derived growth factor (PDGF-BB) and vascular endothelial growth factor (VEGF) (p˂0.05) whereas inhibited GH, IGF-1 and IGFBP-3 post-exercise. In conclusion, PRP improved the inflammatory response and muscle damage by reversing the increased level of iron and suppressed the hepcidin level. On the other hand, PRP had no effect on CK levels, it is not myotoxic as well. In addition, PRP may accelerate the recovery and regeneration of damaged muscles by altering growth factors.</p>