Structural and vibrational study of maprotiline
Makaleler > Tam Makale · 2008
Yazarlar: Aykut Evren YAVUZ, SEVGİ BAYARI, Nadide KAZANCI
Journal of Molecular Structure, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2008, cilt 924-926, ss 313-321
DOI: 10.1016/j.molstruc.2008.11.029
Özet
Maprotiline (N-methyl-9,10-ethanoanthracene-9(10H)-propanamine) is a tetra cyclic antidepressant. It is a highly selective inhibitor of norepinephrine reuptake. The solid and Solution in CCl4 and methanol infrared spectra of maprotiline were recorded. The fully optimized equilibrium structure of maprotiline was obtained from DFT calculations by using the B3LYP functional in combination with 6-31G and 6-311G(d,p) basis sets. The results of harmonic and anharmonic frequency calculations on maprotiline were presented. The vibrational spectra were interpreted, with the aid of normal coordinate analysis based on a scaled quantum mechanical (SQM) force field. Vibrational assignment of all the fundamentals was made using the total energy distribution (TED). The possible interaction between maprotiline and neurotransmitter serotonin (5-HT) were investigated. (C) 2008 Elsevier B.V. All rights reserved.