Holoprozensefali: Bir Olgu Sunumu
Makaleler > Tam Makale · 2014
Yazarlar: Abdullah Erdil, Vildan Ertekin, Handan Alp, İsmail Küçükaslan, Elif Ay
Tıp Araştırmaları Dergisi, Uluslararası, 2014, cilt 12
DOI: 10.18827/etad.95906
Özet
Holoprosencephaly which is characterized by severe facial anomalies is a developmental defect in which the cerebral hemispheres could not split sufficiently into two lobes. The disease can be graded into three as alobar, semilobar and lobar according to the degree of severity. Cyclopia and premaxillary agenesis are the facial findings of the most severe forms while microcephaly and hypoteleorism are the less severe facial anomalies. The prognosis of holoprosencephaly which could also be an isolated anomaly depends on the severity of the brain and facial deformities and associated anomalies. Maternal diabetes, toxoplasmosis, viral enfection and various drugs (phenytoin and salicylates) used during pregnancy have been suggested as risk factors. The aim of this study was to examine the midline defects of a 4 months-old girl who had been diagnosed as lobar holoprosencephaly and discuss these findings in regard with the literature