Prognostic significance and rationality of regular non-invasive imaging follow-up in Takayasu arteritis: A large multicenter cohort study
Makaleler > Tam Makale · 2025
Yazarlar: Fatih Yıldırım, Fatih TAŞTEKİN, Safiye Bakkal, Muhammet Emin Kutu, Tuğba Ocak, Senar San, Aysegul Avcu, Hasan Kocaayan, Sema Işık, Burcu Ceren Uludogan, Gökçe Kenar Artın, Yavuz Pehlivan, Ediz Dalkilic, Nazife Sule Yasar Bilge, Fatma Alibaz-Oner, Ahmet Omma, Ayten Yazici, Ayse Cefle, Servet Akar, Cemal Bes, Gökhan KESER, Fatos Onen, Haner Direskeneli, Nilüfer Alpay Kanıtez
Seminars in Arthritis and Rheumatism, Uluslararası, Wos, 2025, cilt 74, ss 152813-152813
DOI: 10.1016/j.semarthrit.2025.152813
Özet
OBJECTIVES: To investigate the prognostic significance of regular imaging follow-up in Takayasu arteritis (TAK) and assess its rationality. METHODS: This was a retrospective multicenter cohort study. A total of 204 adult patients with TAK from 11 tertiary centers, and 580 imaging studies of these patients were included to encompass all concurrent clinical and laboratory findings. RESULTS: The median follow-up time was 72 (36-96) months. Radiological activity and/or progression was observed in 116 (20 %) of the 580 imaging. A total of 418 (72 %) of the 580 imaging were performed while the physician's global assessment (PGA) was inactive. Radiological activity and/or progression was observed in only 18 (4 %) of the PGA inactive imaging. Younger age [OR 0.980; 95 % CI: 0.961-0.999, P = 0.041] and active PGA [OR 31.766; 95 % CI: 17.961-56.219, P < 0.001] were predictors of radiological activity and/or progression. There was no difference in terms of disease outcomes (MACE, VDI score, and mortality) between patients who underwent regular imaging follow-up regardless of clinical activity once a year or more and others. CONCLUSION: In the absence of clinical activity, the rate of radiological activity and/or progression is very low in patients with TAK during routine follow-up. It seems more reasonable to develop a personalised imaging follow-up plan that takes clinical activity findings into account rather than regular imaging follow-up.