Inhibitors to factor VII in congenital factor VII deficiency
Articles > Article · 2014
Authors: A. Batorova, G. Mariani, K. Kavakli, A. R. de Saez, Ü. Caliskan, M. Karimi, M. Pinotti, M. Napolitano, A. Dolce, B. Sørensen, J. Ingerslev, the STER Study Group
Haemophilia, International, WoS, 2014, vol 20, pp e188-91
DOI: 10.1111/hae.12376
Summary
We performed a prospective study of FVII inhibitor\noccurrence in a large number of patients with FVII\ndeficiency who had received replacement therapy for\nspontaneous or traumatic bleeding episodes, major or\nminor surgical interventions or prophylaxis.Inhibitor development was detected in 2.6% (3/115)\nof patients, but the incidence of de novo inhibitors\nwas 0.8% (1/115). Thus, in this rare bleeding disorder,\nthe development of FVII inhibitors is a very rare\ncomplication as rare as that reported in patients with\nhaemophilia B (prevalence of 2–3%)