GC-MS Investigation of Amaryllidaceae Alkaloids in Galanthus x valentinei nothosubsp. subplicatus
Makaleler > Tam Makale · 2013
Yazarlar: Buket BOZKURT, Strahil Berkov, Jaume Bastida, Gülen İrem KAYA, Mustafa Ali Onur, Nehir SOMER
Natural Product Communications, Uluslararası, Wos, 2013, cilt 8, ss 327-8
DOI: 10.1177/1934578x1300800312
Özet
A GC-MS analysis of alkaloids in the aerial parts and bulbs of Galanthus xvalentinei nothosubsp. subplicatus was performed for the first time. Totally, twenty-six alkaloids were identified, of which tazettine and galanthindole were the major ones. Acetylcholinesterase inhibitory activity of the alkaloidal extracts was determined using modified in vitro Ellman's method. Significant anticholinesterase activity was observed in the tested samples (bulbs: IC50 = 21.3 microg/mL, aerial parts: IC50 = 16.3 microg/mL).