The structure and cytotoxic activity of a new saponin: cephoside A from Cephalaria elazigensis var. purpurea
Makaleler > Tam Makale · 2017
Yazarlar: Peyker KAYCE, Nazlı SARIKAHYA, Murat Pekmez, Nazli Arda, SÜHEYLA KIRMIZIGÜL
TURKISH JOURNAL OF CHEMISTRY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2017, cilt 41, ss 345-353
DOI: 10.3906/kim-1607-68
Özet
Investigation of the aerial parts of Cephalaria elazigensis var. purpurea afforded one new oleanane-type saponin, namely cephoside A (1), and five known natural compounds (2-6). Compound 2, named anemoclemoside A, which is an unusual triterpene glycoside, was identified in the family Dipsacaceae for the first time. Chemical structures of all compounds were determined on the basis of the HRESIMS and 1D and 2D NMR data. Cephoside A (1) and anemoclemoside A (2) were assessed for their cytotoxic activities against HeLa cells, having IC$_{50}$ values of 495 and 135 $\mu $g/mL, respectively.