Determination of 5‐Aminosalicylic Acid by Catalase‐Peroxidase Based Biosensor
Makaleler > Tam Makale · 2009
Yazarlar: Alper AKKAYA, Çağrı ALTUĞ, Nurdan Kasikara PAZARLIOGLU, Erhan DİNÇKAYA
Electroanalysis, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2009, cilt 21, ss 1805-1810
Özet
Abstract 5‐Aminosalicylic acid is an antiinflammatory drug used to treat inflammation of the digestive tract (Crohn's disease) and mild to moderate ulcerative‐colitis. 5‐Aminosalicylic acid is a bowel‐specific aminosalicylate drug. It was developed an amperometric biosensor for determination of 5‐aminosalicylic acid concentration and measurement technique is based on substrate‐competition. The biosensor is more suitable especially for routine 5‐aminosalicylic acid analysis because it is simple to construct and sensitive, specific and does not require any expensive apparatus. This enzyme based biosensor was made with a couple of enzymes which uses the same substrate. The electrode was developed to determine measurement conditions and also characterized.