Isolation of resveratrol from peanut sprouts, radioiodination and investigation of its bioactivity on neuroblastoma cell lines
Makaleler > Tam Makale · 2020
Yazarlar: Fazilet Zümrüt BİBER MÜFTÜLER, Ayfer YURT KILÇAR, Özge KOZGUŞ GÜLDÜ, Emin İlker MEDİNE, Fazilet Zumrut Biber Muftuler
Journal of Radioanalytical and Nuclear Chemistry, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2020, cilt 325, ss 75-84
DOI: 10.1007/s10967-020-07222-5
Özet
Recently, natural antioxidant substances have been purified in a significant increasing incline from different plants for diagnosis and treatment options. In the current study, Resveratrol (RES) was isolated and radioiodinated with iodine-131 ([I-131]iodo-RES). Cell culture studies were conducted on neuroblastoma cells (SY-SH5Y and SK-N-AS) to investigate the bioavailability of [I-131]iodo-RES. The radioiodination yield of RES was 98.81 +/- 0.37% (n = 6). Uptake values up to 25% were observed notably on SK-N-AS cells until 24 h. Briefly; the current study will contribute to the development of novel radiolabeled plant origin agents for the imaging of neuroblastoma cells.